Protein Expression and Purification
Stable Biologics offers protein expression services in E. coli. The stability, solubility, and yield of proteins will be evaluated in different bacterial strains and induction conditions (e.g., temperature, induction time) and assessed by Coomassie blue stained SDS-PAGE and small-scale affinity purifications. Recombinant proteins will be expressed using optimized conditions for expression of soluble protein in 1L shake cultures.
Stable Biologics offers purification services for proteins expressed in E. coli, insect cells, or mammalian cells. Purification services will include cell lysis, purification using a combination of affinity and conventional chromatography steps.
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Founded in 2008 through an academic research collaboration, we provide high-throughput biologics formulation services backed by proven science. Using advanced self-interaction chromatography (SIC), we rapidly screen protein stability with minimal material, delivering results in weeks—not months. With 30+ commercial projects completed, we offer end-to-end support from protein expression and formulation through analytical testing, stability studies, and Phase I manufacturing.